Matrix Science Medica (MSM)

Pterostilbene is a powerful polyphenol and has beneficial properties as an anti-aging ingredient through modulating the hallmarks of aging such as inflammation, oxidative damage, telomere attrition, and cell senescence [1], it has been known to exhibit other health beneficial effects such as antiatherosclerosis, antidiabetic, anti-inflammatory, anti-obesity, antioxidant cardioprotection, cognitive support, and neuroprotection as well [2]; another well-known and pharmacological active polyphenol is resveratrol, but in various studies, pterostilbene was reported to have better bioavailability (80% bioavailability compared to 20% for resveratrol) [1]; pterostilbene has two methoxy (–OCH3) groups which makes it more lipophilic and enhances its membrane permeability, bioavailability, and biological potency [1,2]; caffeine is known for its positive effect on arousal and fatigue, perceptual processing, motor behavior, stress, learning and memory, and energy and performance in limited dose [3,4]; Laurus Labs introduces a combination of pterostilbene and caffeine as pterostilbene caffeine cocrystal (CO-CRYSTAL), a unique and patented ingredient that includes benefits of pterostilbene and caffeine both; highly caffeinated products have been coming under increased regulatory scrutiny regarding the possible risks of consuming high amount of caffeine; CO-CRYSTAL formulation of caffeine offers higher bioavailability and longer half-life and additional functional health benefits of pterostilbene that include cognitive function, antioxidant activity, and heart health; bioavailability and half-life of CO-CRYSTAL were tested in the pharmacokinetic study at Vimta Labs, a National Accreditation Board for Testing and Calibration Laboratories accredited premier preclinical research facility in India; the objective of this study was to assess the comparative pharmacokinetic profile of pterostilbene and caffeine when administered alone as well as in a combined CO-CRYSTAL form in Sprague Dawley rats by the oral route.