Hormonal imbalance is an important biological factor that can affect emotional regulation, psychological stability, and mood disorder burden across different stages of life. Because endocrine changes occur during adolescence, reproductive age, postpartum, midlife, and later adulthood, their influence on mood may vary by age and hormonal pathway. Existing literature has shown strong links between thyroid dysfunction, reproductive hormone imbalance, postpartum endocrine change, and mood-related outcomes such as depression, anxiety, irritability, and emotional instability. However, much of the current research has focused on specific hormonal conditions or isolated life stages, which has limited a broader understanding of how hormonal imbalance affects mood disorders across age groups in an integrated way. This study was therefore conducted to provide a more age-sensitive understanding of the problem. The article examines major hormonal imbalance categories, compares their emotional effects across life stages, and discusses how endocrine disruption contributes to mood disorder burden in different age groups. Overall, the study concludes that hormonal imbalance has a clear but age-dependent influence on mood disorders, and that age-based endocrine interpretation is important for stronger clinical understanding.